cas 66575 29 9 ch55 targetmol Search Results


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t14946  (TargetMol)
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e 616452 targetmol  (TargetMol)
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TargetMol e 616452 targetmol
Figure 2. CDK8 was a barrier of MEF-XEN reprogramming (A) CDK8 activity inhibition assays in vitro for SEL120-34A HCl (control), MSC2530818, <t>E-616452,</t> and A-83-01. (B) qPCR of Sox17, Gata4, Sall4, and Foxa2 in samples with MEF medium, base, CFAE+8+DMSO/BI/MSC, and CFAE+6 treatment and base control for 12 days, respectively (C, CHIR99021; F, forskolin; A, AM580; E, EPZ04777; 6, E-616452; 8, A-83-01; S, SB431542; L, LY364947). Base, XEN basal medium. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001 between CFAE+8+DMSO and indicated samples. Numbers in brackets are the concentrations (mM) of each small molecule.
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cas  (Selleck Chemicals)
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Selleck Chemicals cas
Figure 2. CDK8 was a barrier of MEF-XEN reprogramming (A) CDK8 activity inhibition assays in vitro for SEL120-34A HCl (control), MSC2530818, <t>E-616452,</t> and A-83-01. (B) qPCR of Sox17, Gata4, Sall4, and Foxa2 in samples with MEF medium, base, CFAE+8+DMSO/BI/MSC, and CFAE+6 treatment and base control for 12 days, respectively (C, CHIR99021; F, forskolin; A, AM580; E, EPZ04777; 6, E-616452; 8, A-83-01; S, SB431542; L, LY364947). Base, XEN basal medium. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001 between CFAE+8+DMSO and indicated samples. Numbers in brackets are the concentrations (mM) of each small molecule.
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s2924  (Selleck Chemicals)
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Selleck Chemicals s2924
Figure 2. CDK8 was a barrier of MEF-XEN reprogramming (A) CDK8 activity inhibition assays in vitro for SEL120-34A HCl (control), MSC2530818, <t>E-616452,</t> and A-83-01. (B) qPCR of Sox17, Gata4, Sall4, and Foxa2 in samples with MEF medium, base, CFAE+8+DMSO/BI/MSC, and CFAE+6 treatment and base control for 12 days, respectively (C, CHIR99021; F, forskolin; A, AM580; E, EPZ04777; 6, E-616452; 8, A-83-01; S, SB431542; L, LY364947). Base, XEN basal medium. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001 between CFAE+8+DMSO and indicated samples. Numbers in brackets are the concentrations (mM) of each small molecule.
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tranylcypromine selleck  (Selleck Chemicals)
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Selleck Chemicals tranylcypromine selleck
Figure 2. CDK8 was a barrier of MEF-XEN reprogramming (A) CDK8 activity inhibition assays in vitro for SEL120-34A HCl (control), MSC2530818, <t>E-616452,</t> and A-83-01. (B) qPCR of Sox17, Gata4, Sall4, and Foxa2 in samples with MEF medium, base, CFAE+8+DMSO/BI/MSC, and CFAE+6 treatment and base control for 12 days, respectively (C, CHIR99021; F, forskolin; A, AM580; E, EPZ04777; 6, E-616452; 8, A-83-01; S, SB431542; L, LY364947). Base, XEN basal medium. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001 between CFAE+8+DMSO and indicated samples. Numbers in brackets are the concentrations (mM) of each small molecule.
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s8071  (Selleck Chemicals)
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Figure 2. CDK8 was a barrier of MEF-XEN reprogramming (A) CDK8 activity inhibition assays in vitro for SEL120-34A HCl (control), MSC2530818, <t>E-616452,</t> and A-83-01. (B) qPCR of Sox17, Gata4, Sall4, and Foxa2 in samples with MEF medium, base, CFAE+8+DMSO/BI/MSC, and CFAE+6 treatment and base control for 12 days, respectively (C, CHIR99021; F, forskolin; A, AM580; E, EPZ04777; 6, E-616452; 8, A-83-01; S, SB431542; L, LY364947). Base, XEN basal medium. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001 between CFAE+8+DMSO and indicated samples. Numbers in brackets are the concentrations (mM) of each small molecule.
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pd0325901 selleck  (Selleck Chemicals)
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Selleck Chemicals pd0325901 selleck
Figure 2. CDK8 was a barrier of MEF-XEN reprogramming (A) CDK8 activity inhibition assays in vitro for SEL120-34A HCl (control), MSC2530818, <t>E-616452,</t> and A-83-01. (B) qPCR of Sox17, Gata4, Sall4, and Foxa2 in samples with MEF medium, base, CFAE+8+DMSO/BI/MSC, and CFAE+6 treatment and base control for 12 days, respectively (C, CHIR99021; F, forskolin; A, AM580; E, EPZ04777; 6, E-616452; 8, A-83-01; S, SB431542; L, LY364947). Base, XEN basal medium. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001 between CFAE+8+DMSO and indicated samples. Numbers in brackets are the concentrations (mM) of each small molecule.
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dznep selleck  (Selleck Chemicals)
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Selleck Chemicals dznep selleck
Figure 2. CDK8 was a barrier of MEF-XEN reprogramming (A) CDK8 activity inhibition assays in vitro for SEL120-34A HCl (control), MSC2530818, <t>E-616452,</t> and A-83-01. (B) qPCR of Sox17, Gata4, Sall4, and Foxa2 in samples with MEF medium, base, CFAE+8+DMSO/BI/MSC, and CFAE+6 treatment and base control for 12 days, respectively (C, CHIR99021; F, forskolin; A, AM580; E, EPZ04777; 6, E-616452; 8, A-83-01; S, SB431542; L, LY364947). Base, XEN basal medium. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001 between CFAE+8+DMSO and indicated samples. Numbers in brackets are the concentrations (mM) of each small molecule.
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Image Search Results


Figure 2. CDK8 was a barrier of MEF-XEN reprogramming (A) CDK8 activity inhibition assays in vitro for SEL120-34A HCl (control), MSC2530818, E-616452, and A-83-01. (B) qPCR of Sox17, Gata4, Sall4, and Foxa2 in samples with MEF medium, base, CFAE+8+DMSO/BI/MSC, and CFAE+6 treatment and base control for 12 days, respectively (C, CHIR99021; F, forskolin; A, AM580; E, EPZ04777; 6, E-616452; 8, A-83-01; S, SB431542; L, LY364947). Base, XEN basal medium. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001 between CFAE+8+DMSO and indicated samples. Numbers in brackets are the concentrations (mM) of each small molecule.

Journal: Cell reports

Article Title: Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems.

doi: 10.1016/j.celrep.2023.112566

Figure Lengend Snippet: Figure 2. CDK8 was a barrier of MEF-XEN reprogramming (A) CDK8 activity inhibition assays in vitro for SEL120-34A HCl (control), MSC2530818, E-616452, and A-83-01. (B) qPCR of Sox17, Gata4, Sall4, and Foxa2 in samples with MEF medium, base, CFAE+8+DMSO/BI/MSC, and CFAE+6 treatment and base control for 12 days, respectively (C, CHIR99021; F, forskolin; A, AM580; E, EPZ04777; 6, E-616452; 8, A-83-01; S, SB431542; L, LY364947). Base, XEN basal medium. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001 between CFAE+8+DMSO and indicated samples. Numbers in brackets are the concentrations (mM) of each small molecule.

Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies Anti-hSOX17 R&D Systems Cat# AF1924; RRID:AB_355060 Anti-GATA-4 Santa Cruz Cat# sc-25310; RRID:AB_627667 Anti-Sall4 Abcam Cat# ab29112; RRID:AB_777810 Anti-FOXA2 Abcam Cat# ab108422; RRID:AB_11157157 Anti-Alb BETHYL Cat# A90-134A; RRID:AB_2891982 Donkey anti-Goat IgG (H + L) Cross-Adsorbed Secondary Antibody, Alexa FluorTM 555 Thermo Fisher Scientific Cat# A21432; RRID: AB_2535853 Donkey anti-Goat IgG (H + L) Cross-Adsorbed Secondary Antibody, Alexa FluorTM 488 Thermo Fisher Scientific Cat# A11055; RRID:AB_2534102 Donkey anti-Rabbit IgG (H + L) Highly Cross-Adsorbed Secondary Antibody, Alexa FluorTM 555 Thermo Fisher Scientific Cat# A31572; RRID:AB_162543 Donkey anti-Rabbit IgG (H + L) Highly Cross-Adsorbed Secondary Antibody, Alexa FluorTM 488 Thermo Fisher Scientific Cat# A21206; RRID:AB_2535792 Donkey anti-Goat IgG (H + L) Cross-Adsorbed Secondary Antibody, Alexa FluorTM 555 Thermo Fisher Scientific Cat# A21202; RRID:AB_141607 Bacterial and virus strains TransStbl3 Chemically Competent Cell TransGen Cat# CD521-01 Biological samples Human keloid samples Chinese Academy of Medical Sciences and Peking Union Medical College Ethics approval number: 2022-KY-043 Chemicals, peptides, and recombinant proteins Human FGF2 Dogesce Cat# TP750002 LIF Miltenyi Biotec Cat# 130-095-777 Human FGF4 Peprotech Cat# AF-100-31-25UG Human HGF Peprotech Cat# 100-39-2 EGF Peprotech Cat# 100-47 Human BMP4 Peprotech Cat# 120-05-100 CHIR99021 Selleck Cat# S2924; CAS: 252917-06-9 E-616452 TargetMol Cat# T6337; CAS 446859-33-2 Forskolin TargetMol Cat# T2939; CAS 66575-29-9 CH55 TargetMol Cat# T14946; CAS 110368-33-7 UNC0638 Selleck Cat# S8071; CAS: 1255580-76-7 EPZ00477 Selleck Cat# S7353; CAS: 1338466-77-5 AM580 Selleck Cat# S2933; CAS: 102121-60-8 Tranylcypromine Selleck Cat# S4246; CAS: 1986-47-6 DZNep Selleck Cat# S7120; CAS: 120964-45-6 SGC0946 Selleck Cat# S7079; CAS: 1561178-17-3 5-aza-dC Selleck Cat# S1200; CAS: 2353-33-5 PD0325901 Selleck Cat# S1036; CAS: 391210-10-9 Nicotinamide Selleck Cat# S4785; CAS: 1986-81-8 (Continued on next page) 16 Cell Reports 42, 112566, June 27, 2023

Techniques: Activity Assay, Inhibition, In Vitro, Control